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Oxytocin

Oxytocin is a naturally occurring cyclic peptide hormone composed of nine amino acids. Scientists consider the peptide hormone to be secreted by the pituitary gland and to act as a neurotransmitter within the brain. The synthetic form of the peptide, Recombinant Oxytocin, is a cyclic nonapeptide developed to be analogous to the naturally occurring peptide. Scientists consider oxytocin to be created by the hypothalamus and then secreted and stored in the posterior pituitary gland, potentially released in the event of specific stimulation. Unlike other hormones, naturally occurring Oxytocin has been posited to work via a positive feedback mechanism — the initial secretion of the hormone peptide may lead to further release at higher concentrations and with higher intensity. Considered to be especially pivotal in the process of gestation and labor, Oxytocin may bind with G-protein coupled receptors to potentially increase intracellular calcium levels. This calcium secretion may have various downstream impacts, such as inducing uterine contractions. Once uterine contractions begin, they may stimulate further release of Oxytocin, leading to higher frequency and intensity via the positive feedback mechanism. The peptide also appears to contribute to contractions of myoepithelial cells in the mammary glands, potentially stimulating milk ejection.

$70.00 USD/ 10mg

Technical Specifications

Technical specifications for Oxytocin
Sequence	Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (C1–C6 disulfide)
Molecular Formula	C43H66N12O12S2
Molecular Weight	1007.193 g/mol
Purity	≥98% (HPLC)
Form	Lyophilized powder
Storage	-20°C, desiccated
CAS	50-56-6
Also Known As	endopituitrina

Application Areas

Tendon and ligament healing studies

Muscle injury recovery protocols

Gastrointestinal tissue repair research

Anti-inflammatory pathway research

Wound healing research

Veterinary wound healing applications

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For Research Use Only. Products are not for human or veterinary consumption. Not a drug, dietary supplement, or medical device. Sold exclusively to qualified research professionals.

Bio-Engineered Precision

Scientists consider oxytocin to be created by the hypothalamus and then secreted and stored in the posterior pituitary gland, potentially released in the event of specific stimulation. Unlike other hormones, naturally occurring Oxytocin has been posited to work via a positive feedback mechanism — the initial secretion of the hormone peptide may lead to further release at higher concentrations and with higher intensity.

Considered to be especially pivotal in the process of gestation and labor, Oxytocin may bind with G-protein coupled receptors to potentially increase intracellular calcium levels. This calcium secretion may have various downstream impacts, such as inducing uterine contractions. Once uterine contractions begin, they may stimulate further release of Oxytocin, leading to higher frequency and intensity via the positive feedback mechanism. The peptide also appears to contribute to contractions of myoepithelial cells in the mammary glands, potentially stimulating milk ejection.

Purity Level≥98% (HPLC)

Molecular Weight1007.193 g/mol

Molecular FormulaC43H66N12O12S2

SequenceCys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (C1–C6 disulfide)

Oxytocin Peptide and Dopamine Signaling

Oxytocin might play a role in shaping sexual behavior by possibly influencing the activity of dopamine within central nervous system regions associated with the rewards system, notably the ventral tegmental area (VTA) and the nucleus accumbens. This influence may stem from projections of Oxytocin to the VTA, where the peptide may either augment dopamine release or enhance the sensitivity of dopaminergic neurons. Such an increase in dopaminergic activity may in turn potentially boost sexual motivation and the perception of reward.

Proposed Mechanism

Oxytocin may directly interact with dopaminergic neurons within the VTA by activating specific oxytocin receptors, initiating a sequence of events that culminates in heightened dopamine release within the nucleus accumbens. This sequence may include the stimulation of nitric oxide synthesis within the VTA, hinting at an intricate interplay involving Oxytocin, dopamine, and nitric oxide. Additionally, Oxytocin may exert indirect action on dopaminergic activity across other cerebral locales, including the hippocampus and amygdala, modulating glutamatergic or GABAergic neurons that in turn influence the VTA.

Oxytocin Peptide and Neuroplasticity

Researchers are actively exploring Oxytocin's impact on developing or maintaining neuroplasticity. The peptide is posited to engage with G-protein coupled receptors, which may increase intracellular calcium levels. This elevation in calcium is thought to play a role in neuronal excitability and synaptic modulation, affecting the transmission of signals across neurons.

Signaling Pathway

Oxytocin's potential influence in the brain may extend to neurogenesis and synaptic plasticity, with effects on neural circuit formation and function. At the synaptic level, Oxytocin's actions appear to diverge, potentially enhancing neurotransmitter release in some contexts while diminishing it in others, reflecting a potential ability to modulate the balance between excitation and inhibition. The interactions of Oxytocin with glial cells such as astrocytes further complicate its role in neurotransmitter dynamics, suggesting regulatory influence extending beyond neurons to the supportive environment that nurtures synaptic connections.

Oxytocin Peptide and Labor Induction

The main aim of this clinical study was to determine the rate of cesarean delivery in pregnant females after removing Oxytocin presence once active labor starts compared to females where Oxytocin was given until the maintenance level as determined in the study protocol. A randomized study was conducted on 252 female subjects between 18 to 50 years, divided into two groups.

Study Design

Group A (127 subjects) was continuously given the peptide per study protocol even after reaching active labor (5 cm cervical dilation), while Group B (125 subjects) was given Oxytocin discontinued after active labor induction. After a 24–72 hour study period, there were 32 reported cesarean deliveries in Group A with 10 infants exhibiting abnormalities, compared to 24 cesarean deliveries in Group B with 9 infants exhibiting abnormalities.

Oxytocin Peptide and Autism

The main aim of this clinical study was to evaluate what action, if any, the peptide may exert on research models of autism. A total of 59 autistic males aged 6 to 11 years were examined, with 29 being autistic and the remainder considered control subjects. The plasma levels of Oxytocin were measured in this study.

Key Findings

The researchers reported that autistic subjects exhibited lower levels of peptide hormone than the control subjects. Once the levels of Oxytocin were elevated as part of the study, the VABS score (analytic behavior score) of autistic subjects appeared to improve, suggesting a potential relationship between oxytocin levels and social-behavioral markers in autism models.

Certificates & Testing

Batch-level purity documentation

Every P3X Labs batch is independently tested by a third-party laboratory. COA documents confirm purity, identity, and absence of contaminants. Lot-specific COAs are linked to each shipment via QR code on the vial label.

COA: assigned at fulfillment — scan QR on vial

HPLC tested

Mass spectrometry verified

≥99% purity guaranteed

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